Video-on-Demand Library

01 October 2026

As cancers grow, they can release genetic material such as DNA into the blood stream known as circulating tumour DNA (ctDNA) which can be detected by blood tests. ctDNA has emerged as a promising biomarker over the last few years across several cancer types. However, clear guidance is lacking on which ctDNA metrics are most informative and which statistical modelling frameworks are appropriate to effectively predict long-term clinical responses, support early patient stratification, adaptive decision-making as well as early efficacy assessment. To address this gap, we, on behalf of the Biomarker Special Interest Group of the PSI, conducted a targeted literature review on statistical modelling approaches for ctDNA data to gain insights into different methods and metrics that are mainly used nowadays. In this webinar we discuss the emerging overall themes and summarise the reviewed methods that were published between 2023 and 2025. 

Presenters: Holly Tovey, Rebecca Freudling, Saskia Ständler, Sara Bellinvia, Lidia Sacchetto

 

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