Pre-Clinical SIG (previously TOX SIG) 



Core Committee (L-R): Fetene Tekle (Janssen), Gareth Thomas (former member and chair), Bernd Igl (Boehringer Ingelheim), Eloisa Brook (chair, GlaxoSmithKline), Jim Saul (former member, Covance) and Phillip Jarvis (former member, Novartis). Luc Essermeant (Sanofi), Ezgi Tanriver-Ayder (GlaxoSmithKline), Sarah Vandepaer (GlaxoSmithKline), Dorothee Tamarelle (Sanofi) and Denise Federico (Evotec) have also joined the team.



To provide a forum to discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment and to promote the involvement of Statisticians in these areas.

Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in preclinical (animal and cell based experiments) areas such as:

- Discovery

- Good statistical practice in in-vitro, ex-vivo and in-vivo assay development

- Reproducibility and Translation from pre-clinical to clinical

- Toxicogenomics

- Genetic Toxicology
- Acute Toxicology
- General Toxicology

- Eco-Toxicology
- Toxicokinetics
- DMPK / Pharmacokinetics
- Immuno Toxicology
- Histopathology
- Pharmacology
- Developmental and Reproductive Toxicology

- Carcinogenicity


We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list. 

Find out more in our video overview:


Upcoming Events

The PSI Pre-clinical Special Interest Group have a series of regular FREE webinars dealing with statistical topics faced in pre-clinical and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this year’s webinars. Please note that these events take place online via Zoom, and has a limited number of places available. 



The PSI Pre-Clinical Special Interest Group seminars for 2023 are as follows: 





14 March 2023

End-user Tool for Immunogenicity Cut-points Calculation 

Dr. Els Pattyn, Ablynx

To access the video on demand, please click here

27 June 2023

EC50 Estimation based on Multi-Donor Dose-Response Data

Dr. Weiliang Qiu and Dr. Cheng Wenren, Sanofi

To access the video on demand, please click here
24 October 2023

Adjusting Experimental and Statistical Approaches throughout Preclinical Development Pathways

PD Dr. Ulf Tölch, Berlin Institute of Health at Charité

For more information and to register, please click here



How to get in touch

Please email us with any questions or comments and if you would like to join our mailing list.


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