Pre-Clinical SIG (previously TOX SIG) 



Core Committee (L-R): Fetene Tekle (Janssen), Gareth Thomas (Covance), Bernd Igl (Boehringer Ingelheim), Eloisa Brook (GlaxoSmithKline), Jim Saul (Covance) and Phillip Jarvis (Novartis). Natasha Karp (Astrazeneca) has also recently joined the SIG.



To provide a forum to discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment and to promote the involvement of Statisticians in these areas.


Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in areas such as:

- Discovery

- Good statistical practice in in-vitro, ex-vivo and in-vivo assay development

- Reproducibility and Translation from pre-clinical to clinical

- Toxicogenomics

- Genetic Toxicology
- Acute Toxicology
- General Toxicology

- Eco-Toxicology
- Toxicokinetics
- DMPK / Pharmacokinetics
- Immuno Toxicology
- Histopathology
- Pharmacology
- Developmental and Reproductive Toxicology

- Carcinogenicity


We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list. 

Find out more in our video overview:

Upcoming Events

The PSI Pre-clinical Special Interest Group have a series of regular FREE webinars dealing with statistical topics faced in pre-clinical and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this year’s webinars.


The PSI Pre-Clinical Special Interest Group seminars for 2021 are as follows: 




 Slides/Video on Demand

16 Mar

Beyond the looking glass – Interpreting animal welfare & behaviour by monitoring & assessing mice activity data

Eloisa Brook, Joanna Moore, George Birbeck. GSK


29 Jun

Update from the Carcinogenicity working group

Steve Bailey. Pfizer


12 Oct


Dr Brianna Gaskill. Novartis



For all previous webinars click here.



We are already planning for when we are able to hold face-to-face workshops again.  Watch this space. 



How to get in touch

Join our mailing list by e-mailing this address with brief details of the field(s) you are working in.



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